8 55 in kini 1996 1. We believe however that there is an under recognized cell type seen in a minority of tumors that was described by kini see fig. 1 12 the majority of tumors show classic cytologic features and in particular nuclear features.
The cytologic features of papillary carcinoma of the thyroid both classic and variant types have been well described. The purpose of the present study was to broadly. The distribution of nuclear pore complexes relative to grooves and inclusions has not been described.
Papillary thyroid carcinoma nuclear envelope is decreased in ptcs even though the surface area of the nuclear envelope in ptcs was greater than in follicular samples johannessen et al 1982. Papillary thyroid carcinoma is the most common type of cancer to affect your thyroid a butterfly shaped gland that sits just below your voice box it s only about as big as a quarter but the. Nuclear stratification key feature.
Pseudostratification of the nuclei like in colorectal adenocarcinoma differentiates from tall cell variant. Elongated nuclei similar to colorectal adenocarcinoma key feature. Papillary thyroid carcinoma columnar cell variant general.
One key feature of ptc is its ability to invade adjacent. The tumor usually appears as an irregular solid mass but in rare cases it may have cystic features. It is the most frequent thyroid neoplasm and carries the best overall prognosis.
Papillary thyroid carcinoma ptc is an epithelial malignancy showing evidence of follicular cell differentiation and a set of distinctive nuclear features. The former is useful in identifying the follicular variant of papillary thyroid carcinomas. Characteristic orphan annie eye nuclear inclusions nuclei with uniform staining which appear empty due to powdery chromatin and marginal micronucleoli and psammoma bodies on light microscopy.
Papillary thyroid cancer gets its name from the papillae among its cells visible on microscopy features include.
Papillary thyroid carcinoma nuclear grooves. In h e stained smears of papillary carcinoma the number of cells with nuclear grooves 227 3 99 96 sd was significantly higher as compared to other thyroid disorders p 01 to 001. Eighty eight percent of papillary carcinoma had nuclear grooves in or 20 tumor cells whereas none of the other thyroid diseases exceeded this level. A nuclear groove is an invagination of the nuclear envelope in the longitudinal axis. It can be present in.
It is a characteristic feature of papillary thyroid carcinoma but has also been seen in other types of thyroid neoplasms as well as in non neoplastic thyroid lesions. Ovarian tumors including brenner tumors adult granulosa cell tumors and transitional cell tumors. Among the ptc cases grooved nuclei were found in all 11 100 intranuclear inclusions in nine 82 papillary fragments in seven 64 and psammoma bodies in two 18. Nuclear grooves were also observed in two of the 113 non ptc cases 1 8 both of which were colloid nodules one with extensive hurthle cell change.
Nuclear grooves were also observed in two of the 113 non ptc cases 1 8 both of which were colloid nodules one with extensive hurthle cell change. Among the ptc cases grooved nuclei were found in all 11 100 intranuclear inclusions in nine 82 papillary fragments in seven 64 and psammoma bodies in two 18. Ovarian tumors including brenner tumors adult granulosa cell tumors and transitional cell tumors.
It is a characteristic feature of papillary thyroid carcinoma but has also been seen in other types of thyroid neoplasms as well as in non neoplastic thyroid lesions. It can be present in. A nuclear groove is an invagination of the nuclear envelope in the longitudinal axis.
Eighty eight percent of papillary carcinoma had nuclear grooves in or 20 tumor cells whereas none of the other thyroid diseases exceeded this level. In h e stained smears of papillary carcinoma the number of cells with nuclear grooves 227 3 99 96 sd was significantly higher as compared to other thyroid disorders p 01 to 001.
