Division of anatomic pathology department of pathology and laboratory medicine university of pennsylvania medical center philadelphia pa. Intranuclear inclusions nuclear grooves and psammoma bodies paraganglioma like adenoma of the thyroid. Nuclear overlapping in the form of folded sheets may be observed in some clusters b.
When the changes are focal and mild particularly if the background consists of colloid they are easily recognized as reactive changes 30. Occasionally these cells show nuclear grooves and powdery chromatin. Clump of epithelial cells with attached fibrous tissue tail that has a smooth edge.
Papillary architecture not commonly seen. Changes in chromatin patterns. Some believe grooves should go from edge to edge i e.
Three cytoarchitectural patterns of follicular neoplasms microfollicular trabecular crowded three dimensional groups. As with adenomatous nodules variable degrees of nuclear atypia including chromatin clumping nuclear grooves and irregular nuclear contours may be seen but this atypia is generally not predictive of malignancy. Architecturally hyalinizing trabecular adenoma can mimic medullary carcinoma but long wavy trabeculae are most uncommon in medullary carcinoma and the nuclear features nuclear grooves nuclear pseudoinclusions perinucleolar haloes are also different.
Nuclear chromatin clearing often with condensation or margination along the nuclear membranes resulting in accentuated nuclear. Nuclear chromatin characteristics. Irregular nuclear contours nuclear grooves and folds rat bites or demi lune formations and the presence of intranuclear cytoplasmic inclusions.
A finding by electron microscopy in the nuclei of malignant epithelial cells in which a bleb of cytoplasm prolapses into the nucleus simulating an intranuclear inclusion. Don t miss it obesity associated with lower psa levels in prostate cancer. Other names for nuclear grooves.
Nuclear grooves is from the group.
Nuclear grooves definition. Nuclear grooves and inclusions are important diagnostic features of cancer although intranuclear inclusions are seen in normal epithelial cells 1 in fact nuclear inclusions are commonly found in some benign and malignant tumors including papillary thyroid carcinoma hepatocellular carcinoma melanoma paraganglioma meningioma and pituitary adenoma 2 it is speculated that the nuclear. Definition of nuclear grooves.
Definition of nuclear grooves. Nuclear grooves and inclusions are important diagnostic features of cancer although intranuclear inclusions are seen in normal epithelial cells 1 in fact nuclear inclusions are commonly found in some benign and malignant tumors including papillary thyroid carcinoma hepatocellular carcinoma melanoma paraganglioma meningioma and pituitary adenoma 2 it is speculated that the nuclear.
