Moreover also a number adopted orphan members of the nuclear receptor superfamily such as retinoid x receptors rxrs α β and γ peroxisome proliferator activated receptors ppars α δ and γ liver x receptors lxr α and β and farnesoid x receptor fxr show a similar mode of action but their natural ligands for example 9 cis. To allow researchers to mine this data we developed the data mining tool transcriptomine becnel 2017. In our previous incarnation as the nuclear receptor signaling atlas nursa we curated geo archived rna seq and expression array or transcriptomic datasets involving genetic or small molecule manipulation of nuclear receptors.
We would like to place on record our deep appreciation of the support of niddk over the 15 years of nursa s existence as well as from our community of. Nuclear receptor signaling atlas after more than 15 years of support from niddk and as announced in our last newsletter the nursa website as it currently exists is being retired in march 2020. Signaling pathways involving members of the nuclear receptor nr superfamily of transcription factors their regulatory small molecules ligands and transcriptional coregulators coordinate regulation of gene expression across multiple physiological systems and organs 1 2 over the past 15 years researchers in this field have frequently used transcriptome scale expression.
This video describes the signaling mechanism of intracellular receptors and describes the molecular mechanism underlying signal transduction. In addition to the classic transcriptional response nrs also have a role in rapid non nuclear signaling originating from receptors localized at the plasma membrane. Other nuclear receptors are contstitutively nuclear and their chromatin modifying activities are regulated by ligand binding reviewed in beato et al 1996.
Gronemeyer h gustafsson ja laudet v 2004 principles for modulation of the nuclear receptor superfamily. Integration of multiple signalling pathways through phosphorylation. Rochette egly c 2003 nuclear receptors.
Tata jr 2002 signalling through nuclear receptors. Kojetin dj burris tp 2014 rev erb and ror nuclear receptors as drug targets. Evans rm mangelsdorf dj 2014 nuclear receptors rxr and the big bang.
The good the bad and the future. Ahmadian m suh jm hah n liddle c atkins ar downes m evans rm 2013 pparγ signaling and metabolism.
