Bone scans may also be normal. Larger lesions may be either hyperactive hot or photopenic cold. The bone scan appearance of patients with disseminated multiple myeloma is variable due to the potential lack of osteoblastic activity.
Nuclear medicine bone scintigraphy. However low grade scintigraphic activity has sometimes been reported in histologically proven enostoses 3. There is usually no technetium 99m mdp uptake and a normal bone scan can exclude an osteoblastic metastasis or osteosarcoma.
Low signal intensity on all sequences compatible with compact bone. Skeletal metastases account for 70 of all malignant bone tumors and are seen in a vast number of primary cancers although lung cancer breast cancer renal cell carcinoma and prostate cancer account for approximately 80 of all skeletal metastases 1 this is due to not only the propensity of these tumors to metastasize to bone but also the fact that these are some of the most. Bone scintigraphy is a highly sensitive diagnostic nuclear medicine imaging technique that uses a radiotracer to evaluate the distribution of active bone formation in the skeleton related to malignant and benign diseases as well as physiological processes.
The radionuclide bone scan is the cornerstone of skeletal nuclear medicine imaging. Bone spect of the lumbar spine showed photopenia in the vertebral body of the l. T underwent a second bone scintigram because of low back pain and the scan showed intense uptake in the edge of the l 3 vertebra on both sides and focal areas of abnormal uptake in the right acetabulum and right pelvis and decreased uptake in the thoracic spine was less apparent compared with the first bone scan.
However it is widely recognised that bone scans have limited sensitivity for disease detection and is both insensitive and non specific for determining treatment response at an early enough time point to be clinically useful. The bone scan continues to be recommended for both the staging and therapy response assessment of skeletal metastases from prostate cancer. Bone scintigraphy was performed with bonenavi version 1 and bonenavi version 2 to calculate artificial neural network ann bone scan index bsi and hot spot values with ann 0 5 considered to reflect bone metastasis for the calculation of sensitivity.
Scintigraphy with 99mtc mdp and were diagnosed with bone metastasis of primary breast cancer from january 2012 to november 2014. You might hear a doctor or nurse called this. Nuclear scans are often used to find out whether cancer from another place in your body such as your breast for instance has spread to your bones.
A bone scan in which there is excessive skeletal radioisotope uptake in relation to soft tissues along with absent or faint activity in the genitourinary tract is known as a superscan apart from prostate cancer which is the most common condition associated with a superscan other malignancies like breast cancer lung cancer 1 2 3 4 can cause superscan appearance on.
Nuclear medicine bone scan metastasis. Nuclear medicine techniques designed to identify bone metastases are reviewed. They include planar and whole body single photon emission tomography spet f 18 fluorine and fdg deoxyglucose positron emission tomography pet bone imaging.
They include planar and whole body single photon emission tomography spet f 18 fluorine and fdg deoxyglucose positron emission tomography pet bone imaging. Nuclear medicine techniques designed to identify bone metastases are reviewed.
