Cas pubmed google scholar. Structure 16 1116 1125 2008. A general ran docking site at the nuclear pore complex.
The crystal structure of the ran nup153znf2 complex. The npc is a large structure with a molecular weight of approximately 125 mda in vertebrates and 66. In order to understand how the npc functions it is useful to examine the similarities and differences between npcs from the yeast saccharomyces cerevisiae and the frog xenopus laevis.
Nuclear pore complexes are proteinaceous structures embedded in the double membrane of the nuclear envelope. The acquisition of. Structural studies have now provided atomic resolution crystal structures of most nucleoporins.
Owing to its size and complexity 1 000 protein subunits 110 mda in humans the npc has remained one of the foremost challenges for structure determination. The nuclear pore complex npc serves as the sole bidirectional gateway of macromolecules in and out of the nucleus. With an estimated molecular mass of about 110 125.
The nuclear pore complex npc is the only route of bidirectional cargo transport between the cytoplasm and the nucleus in a eukaryotic cell. The npc serves as a barrier to inhibit the free molecular flux in and out of the nucleus and selectively transports macromolecules. The nuclear pore complex npc is a macromolecular protein assembly embedded in the double lipid bilayer of the nuclear membrane and is the sole gateway of macromolecular traffic between the nucleus and cytoplasm.
It acts as a gatekeeper controlling the transport of molecules between the nucleus and the. In human cells the nucleus is enclosed by a structure called the nuclear pore complex npc. Regulation of mrna trafficking by nuclear pore complexes.
Science 306 1387 1390 10 1126 science 1104808 google scholar bonnet a palancade b.
Nuclear pore complex structure. A nuclear pore is a part of a large complex of proteins known as a nuclear pore complex that spans the nuclear envelope which is the double membrane surrounding the eukaryotic cell nucleus there are approximately 1 000 nuclear pore complexes npcs in the nuclear envelope of a vertebrate cell but it varies depending on cell type and the stage in the life cycle. The nuclear pore complex npc serves as the sole bidirectional gateway of macromolecules in and out of the nucleus. Owing to its size and complexity 1 000 protein subunits 110 mda in humans the npc has remained one of the foremost challenges for structure determination. Nuclear pore complexes npcs are indispensable for cell function and are at the center of several human diseases.
Npcs provide access to the nucleus and regulate the transport of proteins and rna across the nuclear envelope. They are aqueous channels generated from a complex network of evolutionarily conserved proteins known as nucleporins. In this cell science at a glance article and the. Nuclear pore complex structure and dynamics revealed by cryoelectron tomography.
Nuclear pore complex structure and dynamics revealed by cryoelectron tomography. In this cell science at a glance article and the. They are aqueous channels generated from a complex network of evolutionarily conserved proteins known as nucleporins.
Npcs provide access to the nucleus and regulate the transport of proteins and rna across the nuclear envelope. Nuclear pore complexes npcs are indispensable for cell function and are at the center of several human diseases. Owing to its size and complexity 1 000 protein subunits 110 mda in humans the npc has remained one of the foremost challenges for structure determination.
The nuclear pore complex npc serves as the sole bidirectional gateway of macromolecules in and out of the nucleus. A nuclear pore is a part of a large complex of proteins known as a nuclear pore complex that spans the nuclear envelope which is the double membrane surrounding the eukaryotic cell nucleus there are approximately 1 000 nuclear pore complexes npcs in the nuclear envelope of a vertebrate cell but it varies depending on cell type and the stage in the life cycle.
