Although not totally specific they are particularly common in papillary thyroid carcinoma meningioma and usual ductal hyperplasia of the breast and hence may aid in the diagnosis of these entities. Nuclear pseudoinclusions which represent invaginations of cytoplasm into the nucleus are delimited by the nuclear membrane. Architecturally hyalinizing trabecular adenoma can mimic medullary carcinoma but long wavy trabeculae are most uncommon in medullary carcinoma and the nuclear features nuclear grooves nuclear pseudoinclusions perinucleolar haloes are also different.
Whether active stress controls nuclear deformations and how this stress interplays with properties of the ne to control ne dynamics. The current framework emphasizes the key role of the nuclear lamina in nuclear mechanics and its alterations in disease. Nuclear shape is different in stem cells and differentiated cells and reflects important changes in the mechanics of the nuclear envelope ne.
Enml emerin stained nuclear membrane length. E correlation between nuclear area and the rate of hndn. The percentage of cases with nuclear grooves ngs b or intranuclear cytoplasmic inclusions icis d out of all cases in each category is shown in the line plot.
The nuclei were enlarged with nuclear grooves fine pale chromatin and a small distinct nucleolus. The cells formed small cohesive 2 d flat sheets without nuclear crowding and with distinct cell borders and windows between cells resembling features that are associated typically with reparative epithelial cells fig. Don t miss it obesity associated with lower psa levels in prostate cancer.
Other names for nuclear grooves. Nuclear grooves is from the group. Definition of nuclear grooves.
They were inconspicuous and difficult to identify in air dried diff quik stained material. The grooved nuclei were best identified on papanicolaou stained material. Nuclear grooves were also observed in two of the 113 non ptc cases 1 8 both of which were colloid nodules one with extensive hurthle cell change.
Nuclear grooves and inclusions are important diagnostic features of cancer although intranuclear inclusions are seen in normal epithelial cells 1 in fact nuclear inclusions are commonly found in some benign and malignant tumors including papillary thyroid carcinoma hepatocellular carcinoma melanoma paraganglioma meningioma and pituitary adenoma 2 it is speculated that the nuclear.
